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The pain may radiate to the back or abdomen and commonly occurs on the left side of the sternumprecisely why its frequently confused with heart problems

[2] Fawcett, Wayne D .An atlas of fine structure: the cell - its organelles and inclusions [J]

Concurrently, hyperphosphorylation and its abnormal accumulation, coupled with impaired clearance, lead to the formation of NFTs, further compromising neuronal function